Adn-388 Portable Link

ADN‑388 emerged from a structure‑based fragment‑merging campaign that leveraged the crystal structure of the PD‑1/PD‑L1 complex (PDB ID 5J89). The lead series was optimized to improve affinity, solubility, and metabolic stability, culminating in the drug‑like candidate ADN‑388 (C 23 H 27 FN 4 O 2 S; MW = 456 Da). This paper reports the full spectrum of pre‑clinical data that underpin the selection of ADN‑388 for IND‑enabling development.

– Recombinant human PD‑1 (5 µg mL⁻¹) coated plates, detection with biotin‑PD‑L1 and streptavidin‑HRP. ADN‑388 added in 10‑point serial dilutions (0.1 nM‑10 µM). adn-388

¹ Department of Pharmacology, University of X ² Cancer Immunology Laboratory, Institute Y ³ Medicinal Chemistry Division, PharmaZ Inc. – Recombinant human PD‑1 (5 µg mL⁻¹) coated

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ADN‑388 demonstrated dose‑dependent reversal of PD‑1‑mediated suppression without overt cytokine storm in the multiplex panel.